Compact RNA sensors for increasingly complex functions of multiple inputs

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Designing single molecules capable of complex sensing functions is challenging. Now, using crowdsourced RNA designs from the online game Eterna, compact single-molecule sensors have been demonstrated for a variety of tasks, including a complex three-input tub…

Written by: Christian A. Choe, Johan O. L. Andreasson, Feriel Melaine, Wipapat Kladwang, Michelle J. Wu, Fernando Portela, Roger Wellington-Oguri, John J. Nicol, Hannah K. Wayment-Steele, Michael Gotrik, Purvesh Khatri, William J. Greenleaf, Rhiju Das

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https://www.nature.com/articles/s41557-025-01907-8

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