Amyloid precursor protein modulates cerebellar Purkinje cell activity and motor function through regulation of Nav1.6 currents
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Read Full ArticleThe presence of aberrant forms of amyloid precursor protein (APP) is linked to Alzheimer disease, but its loss leads to motor deficits. This study in mice shows that APP supports motor coordination by regulating sodium channels in cerebellar Purkinje cells, e…
Written by: Miao-Jin Ji, Tong-Xuan Wu, Chenhao Tian, Xiang Cao, Ruyuan Wei, Yin-Yin Yang, Xinran Meng, Huanyao Tang, Tiantao Cui, Jiao Yang, Xin Tang, Chao Liu
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