Dynamic metabolic modeling of Streptomyces clavuligerus in complex medium highlights nutrient-dependent metabolic transitions associated with clavulanic acid biosynthesis
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Read Full ArticleBackground Streptomyces clavuligerus is the main industrial producer of clavulanic acid (CA), a potent β-lactamase inhibitor. However, the metabolic interplay linking amino acid utilization, nitrogen regulation, and CA biosynthesis remains poorly understood, …
Written by: Leon F. Toro-Navarro, Laura Pinilla-Mendoza, Rigoberto Ríos-Estepa
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